Cell therapy and Gene therapy are interrelated biomedical research with the effects of repairing genetic diseases direct cause in the DNA or cellular population. These powerful strategies are also being noticed on specific genes and cell sub-populations modulation in acquired diseases in order to re-establish the normal equilibrium condition of cell. In many rare chronic diseases, gene and cell therapy are combined in the development of promising therapies in promoting better life. Cell and gene therapy provide reagents, concepts, and techniques that are elucidating the accurate points of gene regulation, stem cell lineage, cell-cell interactions, feedback loops, cell line development, amplification loops, regenerative capacity, and remodelling of tissue. Cell therapy or cytotherapy in which intact living cellular material is injected into a host body and it is mediated by five primary mechanisms: providing an anti-inflammatory effect, endothelial progenitor cells homing for necessary tissue growth, enhancing tissue remodelling over scar formation, inhibiting apoptosis programmable cell death or necrosis and differentiating tissues into specialized tissue.